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Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms

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It is approved by the Food & Drug Administration for managing glucose (sugar) levels in people with Type 2 diabetes but is used off-label for weight loss

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Unlike older growth-hormone-releasing peptides such as GHRP-6, ipamorelin shows a high degree of selectivity: it raises GH without meaningfully increasing cortisol, aldosterone, or prolactin in adult studies [1]